Veterinary medicine based on montmorillonite clay from Western Kazakhstan for the treatment and prevention of infectious diseases in farm animals

Nurgul Montayeva; Sarsenbek Montayev; Marina Svotina

doi:10.17268/sci.agropecu.2024.036

Autores

Nurgul Montayeva High School of Veterinary Clinical Sciences, Zhangir Khan University, Uralsk, Republic of Kazakhstan.
Sarsenbek Montayev High School of Veterinary Clinical Sciences, Zhangir Khan University, Uralsk, Republic of Kazakhstan.
Marina Svotina High School of Veterinary Clinical Sciences, Zhangir Khan University, Uralsk, Republic of Kazakhstan.

DOI:

https://doi.org/10.17268/sci.agropecu.2024.036

Palavras-chave:

cattle, gastroenteritis, productivity, diet, metabolic processes

Resumo

The relevance of this research is associated with the great potential of using montmorillonite clay for the treatment and prevention of infectious diseases of important farm animals and the lack of knowledge of these issues in modern literature. The paper was aimed at studying the toxicity, therapeutic and prophylactic efficacy of a veterinary drug developed based on montmorillonite clay of Western Kazakhstan for bovine gastroenteritis. The paper involved clinical, laboratory and pathoanatomical research methods. The obtained data were analysed using statistical methods. Oral administration of the developed veterinary drug did not have a significant effect on the parameters of the biochemical blood test of rats (p > 0.05) and the morphology of their internal organs after 2 weeks. The developed drug does not have toxicity; it can be attributed to the class of low-hazard substances. With a high degree of probability (p < 0.05), it can be argued that the veterinary drug improves the results of the standard treatment regimen for acute gastroenteritis in Kazakh whitehead cattle by 15%-30%. With a probability of 95%, it can be argued that the addition of the developed veterinary drug to the diet for 30 days led to a decrease in the incidence of gastroenteritis by 2.3 - 3.5 times among cattle. In addition, metabolic processes in the body of animals significantly (p < 0.05) improved in the three experimental groups, compared with the control group, in which cattle received a standard diet. Pathological and anatomical study and histological examination of organs and tissues of cows did not reveal significant differences between animals from the experimental and control groups. The results obtained may be useful in the development of effective methods for the treatment and prevention of gastroenteritis in cattle.

Referências

Abdelnaby, A., Abdelaleem, N. M., Elshewy, E., Mansour, A. H., & Ibrahim, S. S. (2022). Application of bentonite clay, date pit, and chitosan nanoparticles as promising adsorbents to sequester toxic lead and cadmium from milk. Biological Trace Element Research, 201, 2650-2664. https://doi.org/10.1007/s12011-022-03353-w

Adamis, Z., Williams, R. B., & Fodor, J. (2005). Bentonite, kaolin, and selected clay minerals. Geneva: World Health Organization.

Adryshev, A. K., Strunnikova, N. A., & Karibaeva, M. K. (2008). Extraction of metal ions from contaminated groundwater with zeolites. Bulletin of VKGTU. Ecology, 2, 102-108.

Agougui, C., Cecilia, J. A., Saad, H., Franco-Duro, F., Essid, R., Khabbouchi, M., & Frini-Srasra, N. (2022). Adsorption of Carvone and Limonene from Caraway essential oil onto Tunisian montmorillonite clay for pharmaceutical application. Scientific Reports, 12(1), 19814. https://doi.org/10.1038/s41598-022-24268-5

Baek, M. J., Kim, G. H., Park, J. H., Kim, J., Kang, I. M., Lee, J. I., & Kim, D. D. (2022). Effect of phosphatidylcholine in bentonite-quetiapine complex on enhancing drug release and oral bioavailability. International Journal of Pharmaceutics, 628, 122347. https://doi.org/10.1016/j.ijpharm.2022.122347

Bellaj, M., Naboulsi, A., Aziz, K., Regti, A., Himri, M. E., et al. (2024). Bio-based Composite from Chitosan Waste and Clay for Effective Removal of Congo Red Dye from Contaminated Water: Experimental Studies and Theoretical Insights. Environmental Research, 255, 119089. https://doi.org/10.1016/j.envres.2024.119089

Bezzekhami, M. A., Harrane, A., Belalia, M., Mostefai, A., Belkhir, N. L., & Bououdina, M. (2023). Green synthesis of starch nanoparticles (SNPs) by Esterification with Rosin Acid Catalysed by Maghnite-H+ (Algerian montmorillonite) with enhanced antioxidant activity. Arabian Journal for Science and Engineering, 48(1), 311-326. https://doi.org/10.1007/s13369-022-07033-8

Biyashev, K. B., Makbuz, A. Z., & Biyashev, B.K. (2016). Occurrence of enteroinfectious pathogens in agricultural animals and poultry. Biology and Medicine, 8(2), BM-170-16.

Bueno, I., Ricke, I., Hwang, H., Smith, E., Nault, A., Johnson, T. J., & Singer, R. S. (2023). Efficacy of antibiotic and non-antibiotic interventions in preventing and treating necrotic enteritis in broiler chickens: A systematic review. Avian Diseases, 67(1) 20-32. https://doi.org/10.1637/aviandiseases-D-22-00069

Chen, L., Li, F., Ma, Z., Wang, A., Kang, Y., et al. (2024). Improving Feed Intake and Rumen Fermentation in Lambs Using Mixed-Dimensional Attapulgite Clay to Adsorb Naturally-Occurring Mycotoxins. Journal of Animal Science, 102. https://doi.org/10.1093/jas/skae080

De Baere, S., Ochieng, P. E., Kemboi, D. C., Scippo, M. L., Okoth, S., Lindahl, J. F., Gathumbi, J. K., Antonissen, G., & Croubels, S. (2023). Development of high-throughput sample preparation procedures for the quantitative determination of aflatoxins in biological matrices of chickens and cattle using UHPLC-MS/MS. Toxins, 15(1), 37. https://doi.org/10.3390/toxins15010037

Dushayeva, L., Kushaliev, K., Mardan, D., Kakishev, M., & Sabirzhanov, A. (2013). Immune morphological changes in the body of kazakh white rock calves after vaccination with BCG vaccine and izoniazid drug application. Global Veterinaria, 10(5), 511-519. https://doi.org/10.5829/idosi.gv.2013.10.5.21413

Fiorito, T. M., Icoz, I., & Stotzky, G. (2008). Adsorption and binding of the transgenic plant proteins, human serum albumin, β-glucuronidase, and Cry3Bb1, on montmorillonite and kaolinite: Microbial utilization and enzymatic activity of free and clay-bound proteins. Applied Clay Science, 39(3-4), 142-150. https://doi.org/10.1016/j.clay.2007.07.006

Ghosh, B., & Chakraborty, D. (2023). Antimicrobial applications of clays and their derivatives in protection of human health. In: Clay Minerals: Their Antimicrobial and Antitoxic Applications (pp. 61-78). Cham: Springer.

Gouda, G. A., Khattab, H. M., Abdel-Wahhab, M. A., El-Nor, S. A., El-Sayed, H. M., & Kholif, S. M. (2019). Clay minerals as sorbents for mycotoxins in lactating goat’s diets: Intake, digestibility, blood chemistry, ruminal fermentation, milk yield and composition, and milk aflatoxin M1 content. Small Ruminant Research, 175, 15-22. https://doi.org/10.1016/j.smallrumres.2019.04.003

Guo, H., Wang, P., Liu, C., Chang, J., Yin, Q., Wang, L., Jin, S., Zhu, Q., & Lu, F. (2023). Compound mycotoxin detoxifier alleviating aflatoxin B1 toxic effects on broiler growth performance, organ damage and gut microbiota. Poultry Science, 102(3), 102434. https://doi.org/10.1016/j.psj.2022.102434

Jiang, Y., Ogunade, I. M., Kim, D. H., Li, X., Pech-Cervantes, A. A., et al. (2018). Effect of adding clay with or without a Saccharomyces cerevisiae fermentation product on the health and performance of lactating dairy cows challenged with dietary aflatoxin B1. Journal of Dairy Science, 101(4), 3008-3020. https://doi.org/10.3168/jds.2017-13678

Lahnafi, A., Elgamouz, A., Tijani, N., Jaber, L., & Kawde, A. N. (2022). Hydrothermal synthesis and electrochemical characterization of novel zeolite membranes supported on flat porous clay-based microfiltration system and its application of heavy metals removal of synthetic wastewaters. Microporous and Mesoporous Materials, 334, 111778. https://doi.org/10.1016/j.micromeso.2022.111778

Lin, X., Feng, Y., He, Y., Ding, S., & Liu, M. (2023). Engineering design of asymmetric halloysite/chitosan/collagen sponge with hydrophobic coating for high-performance hemostasis dressing. International Journal of Biological Macromolecules, 237, 124148. https://doi.org/10.1016/j.ijbiomac.2023.124148

Liu, X., Zhang, Y., Wu, H., Tang, J., Zhou, J., Zhao, J., & Wang, S. (2023). A conductive gelatin methacrylamide hydrogel for synergistic therapy of osteosarcoma and potential bone regeneration. International Journal of Biological Macromolecules, 228, 111-122. https://doi.org/10.1016/j.ijbiomac.2022.12.185

Maliuk, M., Tul, O., Kulida, M., & Kovalenko, D. (2024). Prevalence and diagnostic methods of surgical pathology in the digestive system of animals. Ukrainian Journal of Veterinary Sciences, 15(1), 104-121. https://doi.org/10.31548/veterinary1.2024.104

Menta, P., Prim, J., De Oliveira, E., Lima, F., Galvão, K., Noyes, N., Ballou, M., & Machado, V. (2024). Predictive models for metritis cure using farm-collected data, metabolic and inflammation biomarkers, and hemogram variables measured at diagnosis. Journal of Dairy Science. https://doi.org/10.3168/jds.2023-24452

Nuruzzaman, Md., Rahman, M. M., Liu, Y., & Naidu, R. (2016). Nanoencapsulation, nano-guard for pesticides: A new window for safe application. Journal of Agricultural and Food Chemistry, 64(7), 1447-1483. https://doi.org/10.1021/acs.jafc.5b05214

Persano, F., & Leporatti, S. (2022). Nano-clays for cancer therapy: State-of-the art and future perspectives. Journal of Personalized Medicine, 12(10), 1736. https://doi.org/10.3390/jpm12101736

Rapp, D., Schütz, K. E., Ross, C., Sutherland, M. A., Hempstead, M. N., Hannaford, R., Cave, V. M., & Brightwell, G. (2023). Fecal excretion of Campylobacter jejuni by young dairy calves and the relationship with neonatal immunity and personality traits. Journal of Applied Microbiology, 134(5), lxad094. https://doi.org/10.1093/jambio/lxad094

Rong, X., Zhao, G., Fein, J. B., Yu, Q., & Huang, Q. (2019). Role of interfacial reactions in biodegradation: a case study in a montmorillonite, Pseudomonas sp. Z1 and methyl parathion ternary system. Journal of Hazardous Materials, 365, 245-251. https://doi.org/10.1016/j.jhazmat.2018.11.019

Saribayeva, D.A., Biyashev, K.B., Valdovska, A., Sansyzbai, A.R., & Biyashev, B.K. (2015). Study antagonistic activity, the level of resistance to hydrochloric acid and bile probiotic strain Escherichia coli. Journal of Pure and Applied Microbiology, 9(1), 573-578.

Sharaby, M. R., Soliman, E. A., & Khalil, R. (2024). Halochromic smart packaging film based on montmorillonite/polyvinyl alcohol-high amylose starch nanocomposite for monitoring chicken meat freshness. International Journal of Biological Macromolecules, 258, 128910. https://doi.org/10.1016/j.ijbiomac.2023.128910

Umbitaliyev, A. D. (2013). Livestock development in Kazakhstan. Advances in Modern Natural Science, 11, 174-177.

Vasilyanova, L. S. (2016.) Bentonites in ecology. Science News of Kazakhstan, 3(129), 70-101.

Wang, M., Rivenbark, K. J., & Phillips, T. D. (2023). Adsorption and detoxification of glyphosate and aminomethylphosphonic acid by montmorillonite clays. Environmental Science and Pollution Research, 30(5), 11417-11430. https://doi.org/10.1007/s11356-022-22927-8

Wang, Q., Zhan, X., Wang, B., Wang, F., Zhou, Y., et al. (2022). Modified montmorillonite improved growth performance of broilers by modulating intestinal microbiota and enhancing intestinal barriers, anti-inflammatory response, and antioxidative capacity. Antioxidants, 11(9), 1799. https://doi.org/10.3390/antiox11091799

Zhakupova, A. A., Biyashev, K. B., Biyashev, B. K., Ermagambetova, S. E., & Nurgozhayeva, G. M. (2017). Performance test of the drug enterocol. Journal of Pharmaceutical Sciences and Research, 9(10), 1941-1942.

Zhao, C., Yao, J., Knudsen, T. Š., Liu, J., Zhu, X., & Ma, B. (2023). Effect of goethite-loaded montmorillonite on immobilization of metal (loid) s and the micro-ecological soil response in non-ferrous metal smelting areas. Science of the Total Environment, 865, 161283. https://doi.org/10.1016/j.scitotenv.2022.161283