Actividad antifúngica de extractos y compuestos bioactivos de la familia Fabaceae sobre dermatofitos: una revisión

André Jhadir Layza Vega; Guillermo Juan Cox Trigoso; Juan Héctor Wilson Krugg

Autores/as

André Jhadir Layza Vega Escuela de Postgrado, Universidad Nacional de Trujillo, Av. Juan Pablo II s/n – Ciudad Universitaria, Trujillo, Perú. https://orcid.org/0009-0004-2251-1861
Guillermo Juan Cox Trigoso Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Av. Juan Pablo II s/n – Ciudad Universitaria, Trujillo, Perú. https://orcid.org/0000-0002-9793-3311
Juan Héctor Wilson Krugg Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Av. Juan Pablo II s/n – Ciudad Universitaria, Trujillo, Perú. https://orcid.org/0000-0003-1695-3001

Palabras clave:

Fabaceae, Lupinus, dermatofitos, resistencia antifúngica, alcaloides quinolizidínicos, flavonoides

Resumen

Las dermatofitosis son micosis superficiales de alta prevalencia cuya creciente resistencia a antifúngicos convencionales ha incentivado la exploración de alternativas terapéuticas basadas en productos naturales. Esta revisión sintetiza la evidencia publicada entre 2019 y 2025 sobre la actividad antifúngica de extractos y compuestos bioactivos de la familia Fabaceae frente a dermatofitos clínicamente relevantes. Se realizó una búsqueda sistemática en bases de datos internacionales, considerando exclusivamente artículos de acceso abierto en inglés o español. Se incluyeron veinte estudios, de los cuales diez abordaron especies de Fabaceae, destacando Prosopis farcta, Daniellia oliveri, Cassia spp., Lupinus spp. y Calpurnia aurea, con inhibición significativa incluso frente a cepas resistentes a terbinafina. Esta actividad se atribuyó principalmente a alcaloides quinolizidínicos, flavonoides y antraquinonas. Los estudios comparativos evidenciaron sinergias con antifúngicos convencionales y el desarrollo de formulaciones innovadoras. En conjunto, los resultados posicionan a Fabaceae como una fuente promisoria de agentes antifúngicos, aunque se requieren estudios traslacionales y ensayos clínicos para validar su potencial terapéutico.

DOI: http://dx.doi.org/10.17268/rebiol.2025.45.01.10

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