Garlic (Allium sativum L) and Its beneficial properties for health: A Review

Teofilo Espinoza, Emir Valencia, Margarita Albarrán, Dagoberto Díaz, Roberto Quevedo, Oscar Díaz, José Bastías


Generally, chefs use garlic as an ingredient that enhances the sensory qualities of foods. However, recent studies have shown that garlic contains Sulphur compounds, which provide a health benefit. This review identifies and describes those constituents in garlic responsible for their anti-microbial, antioxidant, anti-inflammatory, and in some cases anti-cancer properties. Also, this review reports the chemical and nutritional contents of garlic (Allium sativum L.) and shows its health benefits for humans. A large variability and diversity in the nutritional content of garlic was found in the literature, including functional properties (antioxidant, antimicrobial, antifungal, and immunological), and many health benefit components, such as antihypertensive, hypolipidemic, antiatherogenic, anticarcinogenic, antitumor, antiaggregant, fibrinolytic, immunomodulatory, and antianemic. Allicin and ajoene were identified among some of the compounds in garlic which are beneficial for human health. Quantity varies depending on bulb maturity and harvest location, and values range between approximately 1mg/g and 9mg/g for allicin and 0.12 mg/g to 0.22 mg/g of garlic oil macerate for ajoene.

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Aala, F.; Kalsom, U.; Nulit, R.; Rezaie, S. 2014. Inhibitory effect of allicin and garlic extracts on growth of cultured hyphae. Iran J Basic Med Sci 17: 150-154.

Abdel-Daim, M.; Abdelkhalek, N.; Hassan, A. 2015. Antagonistic activity of dietary allicin against deltamethrin-induced oxidative damage in freshwater Nile tilapia; Oreochromis niloticus. Ecotoxicology and Environmental Safety 111: 146-152.

Abdel-Hafeez, E.; Ahmad, A.; Kamal, A.; Abdellatif, M.; Abdelgelil, N. 2015. In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp. Parasitology Research 114: 3439-3444.

Abid-Essefi, S.; Zaied, C.; Bouaziz, C.; Ben Salem, I.; Kaderi, R.; Bacha, H. 2012. Protective effect of aqueous extract of Allium sativum against zearalenone toxicity mediated by oxidative stress. Experimental and Toxicologic Pathology 64: 689-695.

Addis, W.; Abebaw, A. 2018. Determination of heavy metal concentration in soils used for cultivation of Allium sativum L. (garlic) in East Gojjam Zone, Amhara Region, Ethiopia. Cogent Chemistry 3.

Alkhatib, M.; Binsiddiq, B.; Backer, W. 2017. In Vivo Evaluation of the Anticancer Activity of a Water-in-Garlic Oil Nanoemulsion Loaded with Docetaxel. International Journal of Pharmaceutical Sciences and Research 8: 5373-5379.

Almatroodi, S.A.; Alsahli, M.A.; Almatroudi, A.; Rahmani, A. H. 2019. Garlic and its active compounds: A potential candidate in the prevention of cancer by modulating various cell signalling pathways. Anti-Cancer Agents in Medicinal Chemistry 19: 1314-1324.

Amor, S.; González-Hedström, D.; Martín-Carro, B.; Inarejos-García, A. M.; Almodóvar, P.; Prodanov, M.; García-Villalón, A. L.; García, M. G. 2019. Beneficial effects of an aged black garlic extract in the metabolic and vascular alterations induced by a high fat/sucrose diet in male rats Nutrients 11(1): E153.

Anan, Y.; Yoshida, M.; Hasegawa, S.; Katai, R.; Tokumoto, M.; Ouerdane, L.; Lobinski, R.; Ogra, Y. 2013. Speciation and identification of tellurium-containing metabolites in garlic, Allium sativum. Metallomics 5: 1215-1224.

Baek, S.C.; Nam, K.H.; Yi, S.A.; Jo, M.S.; Lee, K.H.; Lee, Y.H.; Lee, J.; Kim, K.H. 2019. Anti-adipogenic Effect of β-Carboline Alkaloids from Garlic (Allium sativum) Foods 8: 1-11.

Baliga, M.; Shivashankara, A.; Palatty, P.; Dsouza, J.; Arora, R. 2013. Chapter 34 - Protective Effect of Garlic (Allium sativum L.) Against Atherosclerosis A2 - Preedy, Ronald Ross WatsonVictor R. In Bioactive Food as Dietary Interventions for Cardiovascular Disease. (2013, ed.), pp. 591-607. Academic Press, San Diego.

Batiha, E.; Beshbishy, M.; Wasef, G.; Elewa, Y.; Al-Sagan, A.; Abd El-Hack, M.; Taha, A.; Abd-Elhakim, M.; Devkota, P. 2020. Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review. Nutrients 12: 1-21.

Bauer, D.; Redmon, N.; Mazzio, E.; Taka, E.; Reuben, J.; Day, A.; Sadrud-Din, S.; Flores-Rozas, H.; Soliman, K.; Darling-Reed, S. 2015. Diallyl disulfide inhibits TNF alpha induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine 75: 117-126.

Berenyiova A.; Grman M.; Misak A.; Golas S.; Cuchorova J.; S., C. 2020. The possible role of the nitroso-sulfide signaling pathway in the vasomotoric effect of garlic juice Molecules 25: 1-15.

Bhandari, S.; Yoon, M.; Kwak, J. 2014. Contents of Phytochemical Constituents and Antioxidant Activity of 19 Garlic (Allium sativum L.) Parental Lines and Cultivars. Horticulture Environment and Biotechnology 55: 138-147.

Bi, J.; Wang, W.; Du, J.; Chen, K.; Cheng, K. 2019. Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents European Journal of Medicinal Chemistry 179: 233-245.

Blanch, M.; Carro, M.; Ranilla, M.; Viso, A.; Vázquez-Anón, M.; Bach, A. 2016. Influence of a mixture of cinnamaldehyde and garlic oil on rumen fermentation, feeding behavior and performance of lactating dairy cows. Animal Feed Science and Technology 219: 313-323.

Chan, J.; Yuen, A.; Chan, R.; Chan, S. 2013. A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin. Phytotherapy Research 27: 637-646.

Chen, C.; Liu, C.; Cai, J.; Zhang, W.; Qi, W.; Wang, Z.; Liu, Z.; Yang, Y. 2018. Broad-spectrum antimicrobial activity, chemical composition and mechanism of action of garlic (Allium sativum) extracts. Food Control 86: 117-125.

Chen, K.; Nakasone, Y.; Xie, K.; Sakao, K.; Hou, D.-X. 2020. Modulation of allicin-free garlic on gut microbiome. Molecules 25: 2-9.

Chen, K.; Xie, K.; Liu, Z.; Nakasone, Y.; Sakao, K.; Hossain, A.; Hou, D.-X. 2019. Preventive effects and mechanisms of garlic on dyslipidemia and gut microbiome dysbiosis Nutrients 11: 1-17.

Chen, X.; Huang, G. 2020. Synthesis and antioxidant activities of garlic polysaccharide-Fe (III) complex. Journal Pre-proofs 145: 813-818.

Cheng, H.; Huang, G.; Huang, H. 2020. The antioxidant activities of garlic polysaccharide and its derivatives International Journal of Biological Macromolecules 145: 1-19.

Chiavarini, M.; Minelli, L.; Fabiani, R. 2015. Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis. Public Health Nutrition 19: 308-317.

Chiriac, A.; Chiriac, A.; Naznean, A.; Podoleanu, C.; Stolnicu, S. 2017. Self-medication garlic-induced irritant skin lesions - case series. International Wound Journal 14: 1407-1408.

Choi, J.; Cho, S.; Lim, Y.; Lee, J.; Go, D.; Kim, S.; Song, C. 2018. Enhancement of the antimycobacterial activity of macrophages by ajoene. Innate Immunity 24: 79-88.

Cicero, A.; Borghi, C. 2013. Evidence of Clinically Relevant Efficacy for Dietary Supplements and Nutraceuticals. Current Hypertension Reports 15: 260-267.

Elosta, A.; Slevin, M.; Rahman, K.; Ahmed, N. 2017. Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro. Scientific Reports 7(1): 1-9.

Espinoza, D.; Maniscalchi, M.; Ledezma, E.; Arrieche, D. 2015. Ultraestructura de microsporum canis: un caso de tinea capitis tratado tópicamente con ajoene. Saber, Universidad de Oriente 27: 401-405.

Fante, L.; Pelayo, C.; Noreña, Z. 2015. Quality of hot air dried and freeze-dried of garlic (Allium sativum L.) Journal of Food Science and Technology 52: 211-220.

Fashner, J.; Ericson, K.; Werner, S. 2012. Treatment of the Common Cold in Children and Adults. American Family Physician 86: 153-160.

Frankel, F.; Matthew, P.; Elizabeth, R.; Chloe, S.; Oni, T.; Abrielle, W.; Barth, E.; Slejzer, K.; Edelstein, S. 2016. Health Functionality of Organosulfides: A Review. International Journal of Food Properties 19: 537-548.

Fratianni, F.; Ombra, M.; Cozzolino, A.; Riccardi, R.; Spigno, P.; Tremonte, P.; Coppola, R.; Nazzaro, F. 2016. Phenolic constituents, antioxidant, antimicrobial and anti-proliferative activities of different endemic Italian varieties of garlic (Allium sativum L.). Journal of Functional Foods 21: 240-248.

Gao, X.; Xue, Z.; Ma, Q.; Guo, Q.; Xing, L.; Santhanam, R. K.; Zhang, M.; Chen, H. 2020. Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism Journal of Food Biochemistry 44: 1-12.

García, L.; Sánchez-Muniz, F. 2000. Revisión: Efectos cardiovasculares del ajo (Allium sativum). Archivos Latinoamericanos de Nutrición 50.

Gatt, M.; Strahilevitz, J.; Sharon, N.; Lavie, D.; Goldschmidt, N.; Kalish, Y.; Gural, A.; Paltiel, O. 2015. A Randomized Controlled Study to Determine the Efficacy of Garlic Compounds in Patients With Hematological Malignancies at Risk for Chemotherapy-Related Febrile Neutropenia. Integrative Cancer Therapies 14: 428-435.

Ghazanfari, T.; Hassan, Z.; Khamesipour, A. 2006. Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic (Allium Sativum) treatment. Journal of Ethnopharmacology 103: 333-337.

Goncagul, G.; Ayaz, E. 2010. Antimicrobial Effect of Garlic (Allium sativum) and Traditional Medicine. Journal of Animal and Veterinary Advances 9: 1-4.

Guillamón, E. 2018. Efecto de compuestos fitoquímicos del género Allium sobre el sistema inmune y la respuesta inflamatoria. Ars Pharm. 59: 185-196.

Haghi, A.; Azimi, H.; Rahimi, R. 2017. A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer. J Gastrointest 48: 314-320.

Hanen, N.; Fattouch, S.; Ammar, E.; Neffati, M. 2012. Allium Species, Ancient Health Food for the Future? Scientific, Health and Social Aspects of the Food Industry 343-355.

Heine-Broring, R.; Winkels, R.; Renkema, J.; Kragt, L.; van Orten-Luiten, A.; Tigchelaar, E.; Chan, D.; Norat, T.; Kampman, E. 2015. Dietary supplement use and colorectal cancer risk: A systematic review and meta-analyses of prospective cohort studies. International Journal of Cancer 136: 2388-2401.

Herrera, G.; Morales, P.; Fernandez-R.; Sanchez-M.; Camara, M.; Carvalho, A.; Ferreira, I.; Pardo-de-S.; Molina, M.; Tardio, J. 2014. Nutrients, phytochemicals and antioxidant activity in wild populations of Allium ampeloprasum L., a valuable underutilized vegetable. Food Research International 62: 272-279.

Huang, H.; Pan, L.; Pan, S.; Song, M. 2018. Effects of dietary herbal formulae combined by Astragalus polysaccharides, chlorogenic acid and allicin in different combinations and proportions on growth performance, non-specific immunity, antioxidant status, vibriosis resistance and damage indexes of Litopenaeus vannamei. Aquaculture research 49: 701-716.

Jang, H.; Lee, H.; Yoon, D.; Ji, D.; Kim, J.; Lee, C. 2018. Antioxidant and antimicrobial activities of fresh garlic and aged garlic by-products extracted with different solvents. Food Science and Biotechnology 27: 219-225.

Jin, Z.-Y.; Wallar, G.; Zhou, J.-Y.; Yang, J.; Han, R.-Q.; Wang, P.-H.; Liu, A.-M.; Gu, X.-P.; Zhang, X.-F.; Wang, X.-S.; Su, M.; Hu, X.; Sun, Z.; Li, G.; Mu, L.-N.; Lu, Q.-Y.; Liu, X.; Li, L.-M.; He, N.; Wu, M.; Zhao, J.-K.; Zhang, Z.-F. 2019. Consumption of garlic and its interactions with tobacco smoking and alcohol drinking on esophageal cancer in a Chinese population Eur J Cancer Prev 28: 278-286.

Johnson, D. 2018. Ethnobotony, the leaves of life. LULU COM, 2018.

Kallel, F.; Driss, D.; Chaari, F.; Belghith, L.; Bouaziz, F.; Ghorbel, R.; Chaabouni, S. 2014. Garlic (Allium sativum L.) husk waste as a potential source of phenolic compounds: Influence of extracting solvents on its antimicrobial and antioxidant properties. Industrial Crops and Products 62: 34-41.

Kaschula, C.; Roger Hunter, R.; Cotton, J.; Tuveri, R.; Ngarande, E.; Dzobo, K.; Schafer, G.; Siyo, V.; Lang, D.; Kusza, D.; Davies, B.; Katz, A.; Parker, M. 2016. The Garlic Compound Ajoene Targets Protein Folding in the Endoplasmic Reticulum of Cancer Cells. Molecular carcinogenesis 55: 1213-1228.

Khalid, N.; Ahmed, I.; Latif, M. S.; Rafique, T.; Fawad, S. 2014. Comparison of Antimicrobial Activity, Phytochemical Profile and Minerals Composition of Garlic Allium sativum and Allium tuberosum. Journal of the Korean Society for Applied Biological Chemistry 57: 311-317.

Khuda, B.; Das, S.; Saha, S. 2014. Molecular Approaches Toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and Other Signal Pathways. Nutrition and Cancer-an International Journal 66: 194-205.

Kim, J.-S.; Kang, O.-J.; Gweon, O.-C. 2013a. Comparison of phenolic acids and flavonoids in black garlic at different thermal processing steps. Journal of Functional Foods 5: 80-86.

Kim, J.; Jeong, D.; Lee, Y.; Hahn, D.; Nam, J.; Lee, W.; Hong, D.; Kim, S.; Ha, Y. 2018. Development and Metabolite Profiling of Elephant Garlic Vinegar. Journal of Microbiology and Biotechnology 28: 50-58.

Kim, J.S.; Kang, O.J.; Gweon, O. C. 2013b. Changes in the Content of Fat- and Water-soluble Vitamins in Black Garlic at the Different Thermal Processing Steps. Food Science and Biotechnology 22: 283-287.

Kim, Y.J.; Nahm, B.A.; Choi, I.H. 2010. An Evaluation of the Antioxidant and Antimicrobial Effectiveness of Different Forms of Garlic and Bha in Emulsion-Type Sausages During Refrigerated Storage. Journal of Muscle Foods 21: 813-825.

Kłębukowska, L.; Anna Zadernowska, A.; Chajęcka-Wierzchowska, W. 2015. Microbiological contamination of dried and lyophilized garlic as a potential source of food spoilage. Journal of Food Science and Technology 52: 1802-1807.

Kong, X.; Gong, S.; Su, L.; Li, C.; Kong, Y. 2017. Neuroprotective effects of allicin on ischemia-reperfusion brain injury. Oncotarget 8: 104492-104507.

Lanzotti, V.; Barile, E.; Antignani, V.; Bonanomi, G.; Scala, F. 2012. Antifungal saponins from bulbs of garlic, Allium sativum L. var. Voghiera. Phytochemistry 78: 126-134.

Laskar, A. A.; Danishuddin; Khan, S. H.; Subbarao, N.; Younus, H. 2019. Enhancement in the catalytic activity of human salivary aldehyde dehydrogenase by alliin from garlic: Implications in aldehyde toxicity and oral health Current Pharmaceutical Biotechnology 20: 506 - 516.

Lee, G.; Lee, J.; Lee, S. 2015. Antioxidant and Anticoagulant Status Were Improved by Personalized Dietary Intervention Based on Biochemical and Clinical Parameters in Cancer Patients. Nutrition and Cancer - An International Journal 67: 1083-1092.

Lee, H.; Heo, J.-W.; Kim, A.-R.; Kweon, M.; Nam, S.; Lim, J.-S.; Sung, M.-K.; Kim, S.-E.; Ryu, J.-H. 2019a. Z-ajoene from crushed garlic alleviates cancer-induced skeletal muscle atrophy Nutrients 11: 1-17.

Lee, H. J.; Jeong, J. H.; Ryu, J.-H. 2019b. Anti-pancreatic cancer activity of Z-ajoene from garlic: An inhibitor of the Hedgehog/Gli/FoxM1 axis. Journal of Functional Foods 56: 102-109.

Lemus-Espinoza, L.; Maniscalchi, M.; Ledezma, E. 2013. Alteraciones morfométricas en células de Microsporum canis expuestas a diferentes concentraciones de ajoene. Saber, Universidad de Oriente, Venezuela 25: 279-284.

Lestari, S.R.; Rifai, M. 2019. The effect of single-bulb garlic oil extract toward the hematology and histopathology of the liver and kidney in mice Brazilian Journal of Pharmaceutical Sciences 55: 1-8.

Leyva, J.; Ortega-Ramirez, L.; Ayala-Zavala, J. 2016. Chapter 49 - Garlic (Allium sativum Linn.) Oils A2 - Preedy, Victor R. In Essential Oils in Food Preservation, Flavor and Safety. pp. 441-446. Academic Press, San Diego.

Lin, S.-C.; Chagnaadorj, A.; Bayarsengee, U.; Leung, T.-K.; Cheng, C.-W. 2019. The compound, diallyl disulfide, enriched in garlic, prevents the progressiodoxorubicin-induced nephropathy Food Science and Technology 39: 1040-1046.

Liu, X.; Baecker, A.; Wu, M.; Zhou, J.-Y.; J., Y.; Han, R.-Q.; Wang, P.-H.; Liu, A.-M.; Gu, X.; Zhang, X.-F.; Wang, X.-S.; Su, M.; Hu, X.; Sun, Z.; Li, G.; Jin, Z.-Y.; Jung, S. Y.; Mu, L.; He, N.; Lu, Q.-Y.; Li, L.; Zhao, J.-K.; Zhang, Z.-F. 2019. Raw garlic consumption and risk of liver cancer: A population-based case-control study in Eastern China Nutrients 11: 1-15.

Liu, Y.; Song, M.; Che, T.; Bravo, D.; Maddox, C.; Pettigrew, J. 2014. Effects of capsicum oleoresin, garlic botanical, and turmeric oleoresin on gene expression profile of ileal mucosa in weaned pigs. Journal of Animal Science 92: 3426-3440.

Lolok, N.; Mashar, H.M.; Annah, I.; Saleh, A.; Yuliastri, W.O.; Isrul, M. 2019. Antidiabetic effect of the combination of garlic peel extract (Allium sativum) and onion peel (Allium cepa) in rats with oral-glucose tolerance method Research Journal of Pharmacy and Technology 12: 2153-2156.

Martins, N.; Petropoulos, S.; Ferreira, I. 2016. Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: A review. Food Chemistry 211: 41-50.

Mbaveng, A.; Ngamenib, B.; Kuete, V.; Simob, I.; Ambassab, P.; Royc, R. 2008. Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae). JEthnopharmacol 116: 483-489.

Mendez, C.; Rodriguez, E.; Romero, C.; Mata, M.; Gonzalez, M.; Isasa, M. 2011. Vitamin C and organic acid contents in Spanish oGazpachoo soup related to the vegetables used for its elaboration process Contenidos de vitamina C y acidos organicos en Gazpacho y en las hortalizas usadas en su elaboracion. Cyta-Journal of Food 9: 71-76.

Miron, T.; Bercovici, T.; Rabinkov, A.; Wilchek, M.; Mirelman, D. 2004. [3H] Allicin: Preparation and Applications. Analytical Biochemistry 331: 364–369.

Moneim, A. 2015. Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease. Current Alzheimer Research 12: 335-349.

Morales-González, J.A.; Madrigal-Bujaidar, E.; Sánchez-Gutiérrez, M.; Izquierdo-Vega, J.A.; Carmen Valadez-Vega, M.D.; Álvarez-González, I.; Morales-González, A.; Madrigal-Santillán, E. 2019. Garlic (Allium sativum L.): A brief review of its antigenotoxic effects. Foods 8(8): E343.

Nieto, G.; Skibsted, L.; Andersen, M.; Ros, G. 2012. Actividad antioxidante y prooxidante del aceite esencial de ajo por resonancia de spin electrónica. An. Vet. (Murcia): 23-33.

Ohtani, M.; Nishimura, T. 2020. Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing intercellular adhesion molecule-1 expression and IL-6. Biomedical Reports 12: 99-108.

Oza, R.; Garcellano, M. 2015. Nonpharmacologic Management of Hypertension: What Works? American Family Physician 91: 772-776.

Petropoulos, S.; Fernandes, A.; Barros, L.; Ciric, A.; Sokovic, M.; Ferreira, I. 2018. Antimicrobial and antioxidant properties of various Greek garlic genotypes. Food Chemistry 245: 7-12.

Pirak, T.; Jangchud, A.; Jantawat, P. 2012. Characterisation of physical, chemical and antimicrobial properties of allicin-chitosan complexes. International Journal of Food Science and Technology 47: 1339-1347.

Popa, C.; Dumitras, D.; Patachia, M.; Stefan, B. 2015. Improvement of a photoacoustic technique for the analysis of non-organic bananas during ripening process. Romanian Journal of Physics 60: 1132-1138.

Popa, C.; Petrus, M. 2017. Heavy metals impact at plants using photoacoustic spectroscopy technology with tunable CO2 laser in the quantification of gaseous molecules. Microchemical Journal 134: 390-399.

Quesada, I.; de Paola, M.; Torres-Palazzolo, C.; Camargo, A.; Ferder, L.; Manucha, W.; Castro, C. 2020. Effect of Garlic’s Active Constituents in Inflammation, Obesity and Cardiovascular Disease Current Hypertension Reports 22: 1-10.

Ramírez-Concepción, H.R.; Castro-Velascoa, L.N.; Martínez-Santiagoa, E. 2016. Efectos Terapéuticos del Ajo (Allium Sativum) Salud y Administración 3: 39-47.

Ried, K. 2016. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates immunity: An Updated Meta-analysis and Review. Sociedad Americana para la Nutrición 146: 389S-396S.

Rodrigues, C.; Percival, S.S. 2019. Immunomodulatory effects of glutathione, garlic derivatives, and hydrogen sulfide Nutrients 11(2): 295.

Rossi, G.; Schiavon, S.; Lomolino, G.; Cipolat-Gotet, C.; Simonetto, A.; Bittante, G.; Tagliapietra, F. 2018. Garlic (Allium sativum L.) fed to dairy cows does not modify the cheese-making properties of milk but affects the color, texture, and flavor of ripened cheese. Journal of Dairy Science 101: 2005-2015.

San-blas, G.; San-blas, F.; Gil, F.; Marino, L.; Apitz-Castro, R. 1989. Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by Ajoene. Antimicrobial agents and chemotherapy 33: 1641-1644.

Santhosha, S.; Jamuna, P.; Prabhavathi, S. 2013. Bioactive components of garlic and their physiological role in health maintenance: A review. Food Bioscience 3: 59-74.

Schimmel, J.; Camarena-Michel, A.; Hoyte, C. 2019. Pediatric Cases Involving Chemical Burns to Garlic Used to Treat Warts Dermatitis 30: 80-82.

Shafiur, M. 2007. La alicina y otros componentes activos funcionales en Ajo: Beneficios para la salud y la biodisponibilidad. International Journal of Food Properties 10: 245-268.

Si, L.; Lin, R.; Jia, Y.; Jian, W.; Yu, Q.; Wang, M.; Yang, S. 2019. Lactobacillus bulgaricus improves antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus: A randomized control trial Bioscience Reports 39: 1-19.

Singh, T.; Kumar, D.; Tandan, S.; Mishra, S. 2009. Inhibitory effect of essential oils of Allium sativum and Piper longum on spontaneous muscular activity of liver fluke, Fasciola gigantica. Experimental Parasitology 123: 302-308.

Siyo, V.; Schäfer, G.; Hunter, R.; Grafov, A.; Grafova, I.; Nieger, M.; Katz, A.; Parker, M.; Kaschula, C. 2017. The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153. Molecules 22: 1-19.

Somman, A.; Siwarungson, N. 2015. Comparison of antioxidant activity and tyrosinase inhibition in fresh and processed white radish, garlic and ginger. Journal of Food Measurement and Characterization 9: 369-374.

Suleria, H.; Butt, M.; Khalid, N.; Sultan, S.; Raza, A.; Aleem, M.; Abbas, M. 2015. Garlic (Allium sativum): diet-based therapy of 21st century a review. Asian Pacific Journal of Tropical Disease 5: 271-278.

Sun, Y.; Wang, W. 2018. Changes in nutritional and bio-functional compounds and antioxidant capacity during black garlic processing. Journal of Food Science and Technology 55: 479-488.

Szychowski, K.; Rybczynska-Tkaczyk, K.; Gawel-Beben, K.; Swieca, M.; Karas, M.; Jakubczyk, A.; Matysiak, M.; Binduga, U.; Gminski, J. 2018. Characterization of Active Compounds of Different Garlic (Allium sativum L.) Cultivars. Polish Journal of Food and Nutrition Sciences 68: 73-81.

Tocmo, R.; Wang, C.; Liang, D.; Huang, D. 2015. Organosulphide profile and hydrogen sulphide-releasing capacity of garlic (Allium sativum L.) scape oil: Effects of pH and cooking. Journal of Functional Foods 17: 410-421.

Touloupakis, E.; Ghanotakis, D. 2010. Nutraceutical Use of Garlic Sulfur-Containing Compounds. In Bio-Farms for Nutraceuticals: Functional Food and Safety Control by Biosensors. Vol. 698, pp. 110-121.

Tsai, J.-C.; Chen, Y.-A.; Wu, J.-T.; Cheng, K.-C.; Lai, P.-S.; Liu, K.-F.; Lin, Y.-K.; Huang, Y.-T.; Hsieh, C.-W. 2019. Extracts from fermented black garlic exhibit a hepatoprotective effect on acute hepatic injury Molecules 24: 1-13.

Turhan, A.; Kuscu, H.; Ozmen, N.; Demir, A. O. 2014. The Effect of Different Salinity Levels on the Yield and Some Quality Parameters of Garlic (Allium sativum L.). Tarim Bilimleri Dergisi-Journal of Agricultural Sciences 20: 280-287.

Upadhyay, R. 2016. Garlic: A potential source of pharmaceuticals and pesticides: A review. International Journal of Green Pharmac 10: S1-S28.

Vadekeetil, A.; Kaur, G.; Chhibber, S.; Harjai, K. 2015. Applications of thin-layer chromatography in extraction and characterisation of ajoene from garlic bulbs. Natural Product Research 29(8): 768-771.

Varga-Visi, E.; Jócsák, I.; Ferenc, B.; Végvári, G. 2019. Effect of crushing and heating on the formation of volatile organosulfur compounds in garlic. CYTA – Journal of food 17: 796-803.

Wang, X.; Liu, R.; Yang, Y.; Zhang, M. 2015. Isolation, purification and identification of antioxidants in an aqueous aged garlic extract. Food Chemistry 187: 37-43.

Wang, X.; Yang, Y.; Liu, R.; Zhou, Z.; Zhang, M. 2016a. Identification of Antioxidants in Aged Garlic Extract by Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry. International Journal of Food Properties 19: 474-483.

Wang, Y.; Sun, Z.; Chen, S.; Jiao, Y.; Bai, C. 2016b. Mediada por la activación de JNK ROS / p38 contribuye en parte al efecto pro-apoptótica de ajoene en las células de adenocarcinoma de pulmón. Biología tumoral 37: 3727-3738.

Weiss, N.; Papatheodorou, L.; Morihara, N.; Hilge, R.; Ide, N. 2013. Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. Journal of Ethnopharmacology 145: 162-167.

Wu, C.; Wang, M.; Dong, Y.; Cheng, Z.; Meng, H. 2015. Growth, bolting and yield of garlic (Allium sativum L.) in response to clove chilling treatment. Scientia Horticulturae 194: 43-52.

Xu, X.; Miao, Y.; Yu Chen, J.; Zhang, Q.; Wang, J. 2015. Effective production of S-allyl-L-cysteine through a homogeneous reaction with activated endogenous γ-glutamyltranspeptidase in garlic (Allium Sativum). Journal of Food Science and Technology 52: 1724-1729.

Yoo, M.; Lee, S.; Kim, S.; Shin, D. 2014. Optimizing conditions for E‐and Z‐ajoene formation from garlic juice using response surface methodology. Food Science & Nutrition 2: 605-611.

Yoshimoto, N.; Onuma, M.; Sugino, Y.; Nakabayashi, R.; Imai, S.; Tsuneyoshi, T.; Sumi, S.; Saito, K. 2015. Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic. Plant Journal 83: 941-951.

Zhang, L.; Guan, P.; Zhang, Z.; Dai, Y.; Hao, L. 2018. Physico-chemical characteristics of complexes between amylose and garlic bioactive components generated by milling activating method. Food Research International 105: 499-506.

Zhang, L.; Liu, Y. 2020. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol 92: 479-490.

Zhang, X.; Shi, Y.; Wang, L.; Li, X.; Zhang, S.; Wang, X.; Jin, M.; Hsiao, C.-D.; Lin, H.; Han, L.; Liu, K. 2019. Metabolomics for Biomarker Discovery in Fermented Black Garlic and Potential Bioprotective Responses against Cardiovascular Diseases. Journal of Agricultural and Food Chemistry 67: 1-34.


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Agroindustrial Science by Universidad Nacional de Trujillo is licensed under a Creative Commons Reconocimiento-NoComercial 3.0 Unported License.

ISSN: 2226-2989 (electrónico); DOI: 10.17268/agroind.sci

Dirección: Av Juan Pablo II s/n. Ciudad Universitaria. Facultad de Ciencias Agropecuarias. Universidad Nacional de Trujillo. Trujillo, Perú.